101 Guide to “The Entourage Effect”

Dive into the heart of the cannabis experience with our concise guide to the entourage effect. This phenomenon suggests that the whole is greater than the sum of its parts, with cannabinoids, terpenes, and flavonoids working together to enhance both therapeutic and psychoactive effects. Unlock the full potential of cannabis by understanding how these compounds interact, paving the way for a more informed and enriched consumption experience.

Unveiling the Concept of the Entourage Effect

The captivating phenomenon known as the “Entourage Effect” is the intricate interplay between various compounds within the cannabis plant, manifesting their synergistic functions and profound impact on the human body. 

  • Over 100 cannabinoids, 200+ terpenes and 40 flavonoid are found within cannabis. They work together to have a cumulative impact on the healing effects and mitigate the side effects. 
  • The natural complexity and synergy of these compounds offer a more balanced and nuanced effect, embodying the concept that the whole plant’s impact is greater than its isolated parts.
  • Full spectrum extracts such as Fraser Valley Hash Rosin & Phoenix Tears & RSO because these maintain the plant’s entire compound profile are often mentionned when talking about this concept (along with the regular dried flowers)

Now that you have a better grasp of what is the entourage effect let’s jump into its components.

3 Key Players: Cannabinoids, Terpenes & Flavonoids


popular cannabinoids

Illustration provided by ZebraCBD

Cannabinoids is the unique chemical compounds of cannabis. THC (tetrahydrocannabinol) and CBD (cannabidiol) are the most well-known, but over one hundred other cannabinoids including CBG, CBC, CBN etc, also influence the overall function of the plant. Different cannabinoids bind with the body’s endocannabinoid system in different ways and modulate diverse physical processes. Here are some health benefits of the cannabinoids

  • Control of Vomiting and Nausea in Chemotherapy: Synthetic forms of THC, an active component of cannabis, are in FDA-approved drugs to mitigate these side effects in cancer treatment.
  • Pain Management: It has shown effectiveness in reducing pain linked to nerve damage, cancer, multiple sclerosis (MS), and rheumatoid arthritis, albeit modestly.
  • Muscle Spasms Reduction: Particularly in MS patients, cannabis has been noted to ease muscle spasms. The evidence for its effectiveness in spinal cord injuries is less conclusive.


Terpenes, which are aromatic oils present in cannabis and many other plants are also essential. They not only determine the cannabis aroma and taste, but these substances also have therapeutic properties. Terpenes like myrcene, limonene, and linalool have been investigated for their possible: While cannabis boasts around 400 known terpenes, only a select few have been extensively studied for their specific health benefits. Here’s a brief overview of some notable terpenes found in cannabis and their potential health benefits:

  • Beta-Caryophyllene: Found in cloves, rosemary, and hops, this terpene might offer relief from anxiety and depression, showcasing the therapeutic potential beyond its culinary uses.
  • Beta-Pinene: Evoking the fresh aroma of a coniferous forest, beta-pinene is believed to have antidepressant and anticancer properties, highlighting nature’s intricate connections to wellness.
  • Humulene: Present in ginseng, humulene is celebrated for its energizing effects, a testament to its long-standing value in folk medicine.


Flavonoids in cannabis not only add vibrant color but are also pivotal for the plant’s taste and potential health effects. Over 20 flavonoids identified in Cannabis Sativa play roles beyond aesthetics. Comparable to the flavonoid-rich foods like dark chocolate and berries, cannabis flavonoids, particularly unique ones known as cannflavins, offer intriguing health potentials. Here are a few examples of thsoe flavonoids:

  • Kaempferol: Known for its anticancer, antimicrobial, and antioxidant properties. It’s also been studied for its potential to provide neuroprotective and anti-inflammatory benefits.
  • Quercetin: This flavonoid has a broad range of health benefits, including anti-inflammatory and antioxidant effects. It’s also been explored for its anticancer, cardioprotective, and neuroprotective properties.

Synergy Over Singularity

The entourage effect suggests that a whole-plant extract, which includes a diverse profile of cannabinoids, terpenes, and flavonoids, might offer more significant therapeutic benefits than any single compound isolated.

Consider the analogy of multi-vitamin tabs, designed to deliver a balanced mix of essential nutrients in a single dose. This blend ensures that the body receives a comprehensive spectrum of vitamins and minerals, which can work together, enhancing each other’s absorption and effectiveness—akin to the entourage effect in cannabis.

Natural Combination: Terpenes, cannabinoids, and flavonoids each have unique health benefits. Just as a balanced diet or multi-vitamins offer broader health benefits compared to isolated nutrients, whole-plant cannabis offers a more comprehensive therapeutic potential.

Modulation of Effects: For instance, CBD can mitigate some of THC’s psychoactivity, while specific terpenes can enhance or modulate the overall effect.

  • Example: Terpenes contribute to aroma and mood enhancement; cannabinoids like THC and CBD offer pain relief and anti-inflammatory properties; flavonoids provide antioxidant support.


Looking through the lens of the Entourage Effect reveals the complexity and multi-faceted nature of the cannabis plant with the idea of utilizing the whole range of compounds, the synergetic effect of which can lead to optimal results; one should consider exploring the possibility of using full-spectrum products.

Through the acknowledgment and utilization of cannabinoids and terpenes’ synergistic properties, we can take the first steps toward a more thorough and adaptive way of using cannabis-based remediation. Considering the further disclosure of highly intriguing secrets of this magical plant, the Entourage Effect is, in fact, a living example of nature’s strong synergy that hides within the cannabis plant.